Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27976637 | 0.85 | CYP2D6 (0.46) | MEN1KMT2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL27776265 | 0.85 | CYP1A2 (0.50) | MEN1KMT2ACYP2D6KCNH2 | |
| SCHEMBL27704299 | 0.83 | CYP1A2 (0.52) | MEN1KMT2ACYP2D6KCNH2CHRM2 | |
| SCHEMBL27627412 | 0.83 | CYP1A2 (0.52) | MEN1KMT2ACYP2D6KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL27922707 | 0.82 | CYP1A2 (0.50) | MEN1KMT2ACYP2D6KCNH2CHRM2 | |
| SCHEMBL28762467 | 0.81 | CYP2D6 (0.37) | MEN1KMT2AOPRD1SLC6A3CYP2D6 | |
| SCHEMBL27560043 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2AOPRD1SLC6A4SLC6A2 | |
| SCHEMBL17956885 | 0.81 | CYP2D6 (0.34) | MEN1KMT2AOPRD1SLC6A3CYP2D6 | |
| SCHEMBL27889146 | 0.81 | ALDH1A1 (0.47) | — | |
| SCHEMBL28274309 | 0.80 | HRH3 (0.38) | MEN1KMT2AOPRD1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036006-A | The preparation and use of pyrimidone derivatives | 癌症研究科技有限公司 | 2019-07-19 | — | — | CN | claimed |
| CN-107501274-B | It can be used as the compound of ATR kinase inhibitor | Votex Pharmaceutical Co., Ltd. (US) | 2019-11-22 | — | — | CN | disclosed |
| CN-107501275-B | It can be used as the compound of ATR kinase inhibitor | Votex Pharmaceutical Co., Ltd. (US) | 2019-11-22 | — | — | CN | disclosed |
| CN-110248939-A | tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-106132963-B | (5, 6-dihydro) pyrimido [4,5-e ] indolizines | 荷兰转化研究中心有限责任公司 | 2019-08-06 | — | — | CN | disclosed |
| CN-110036006-A | The preparation and use of pyrimidone derivatives | 癌症研究科技有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-110003217-A | It can be used for treating the composition of illness relevant to KIT | 蓝图药品公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105658652-B | Compositions useful for treating disorders associated with KIT | 蓝图药品公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-105829308-B | Isochromene derivatives as phosphoinositide 3-kinase inhibitors | 奇斯药制品公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-109071561-A | Thienopyrazine formamide as ubiquitin-specific protease inhibitor | 福马治疗股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-101516888-A | Pyrazolo [1, 5-a] pyrimidine derivatives and their therapeutic use | NOVARTIS AG (CH) | 2009-08-26 | — | — | CN | disclosed |
| CN-101282972-A | Piperidine and piperazine derivatives as P2X3 antagonists | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | CN | disclosed |
| CN-101065385-A | Rifamycin derivatives for treating microbial infections | CUMBRE PHARMACEUTICALS INC (US) | 2007-10-31 | — | — | CN | disclosed |
| CN-1290847-C | Aza-aryl piperazines | HOFFMANN LA ROCHE (CH) | 2006-12-20 | — | — | CN | disclosed |
| CN-1738804-A | Pyrazole compounds | VERNALIS CAMBRIDGE LTD (GB) | 2006-02-22 | — | — | CN | disclosed |
| CN-1625558-A | Aza-arylpiperazines | HOFFMANN LA ROCHE (CH) | 2005-06-08 | — | — | CN | disclosed |
| CN-1198825-C | 8-phenyl-6, 9-dihydro- [1,2,4] triazolo [3, 4-i ] purin-5-one derivatives | ALMIRALL PRODESFARM S A (ES) | 2005-04-27 | — | — | CN | disclosed |
| CN-1420882-A | Substd. oxoazaheterocyclyl compounds | AVENTIS PHARM PROD INC (US) | 2003-05-28 | — | — | CN | disclosed |
| CN-1378538-A | Diazocine-diketone derivatives and use as tryptase inhibitor thereof | BYK GULDEN LOMBERG CHEM FAB (DE) | 2002-11-06 | — | — | CN | disclosed |
| CN-1374962-A | 8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i] purin-5-one derivatives | ALMIRALL PRODESFARM S A (ES) | 2002-10-16 | — | — | CN | disclosed |