Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27471099 | 0.99 | NPC1 (0.41) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27488950 | 0.94 | NPBWR1 (0.40) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27508688 | 0.87 | NPBWR1 (0.36) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27487167 | 0.85 | NPBWR1 (0.40) | NPC1RAB9ANPBWR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27522224 | 0.84 | PTGS2 (0.49) | — | |
| SCHEMBL27472457 | 0.83 | NPBWR1 (0.43) | NPC1RAB9ANPBWR1SMN1; SMN2LMNA | |
| SCHEMBL7517074 | 0.83 | PTGS2 (0.48) | — | |
| SCHEMBL27472461 | 0.83 | PTGS2 (0.46) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27472006 | 0.83 | NPBWR1 (0.42) | NPC1RAB9ANPBWR1SMN1; SMN2LMNA | |
| SCHEMBL27470569 | 0.82 | SMO (0.37) | CYP1A2NPBWR1ALDH1A1MCHR1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167687-C | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ���Ͽع�����˾ | 2004-09-22 | — | — | CN | disclosed |
| CN-1277605-A | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ABBOTT LAB (US) | 2000-12-20 | — | — | CN | disclosed |