Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432004 | 0.74 | HTT (0.35) | HTTARG1EGLN1APLNR | |
| SCHEMBL3939441 | 0.68 | HTT (0.38) | HTTHDAC1SMN1; SMN2CYP2C19APLNR | |
| SCHEMBL7271734 | 0.68 | HTT (0.38) | HTTHDAC1SMN1; SMN2CYP2C19APLNR | |
| SCHEMBL7994230 | 0.65 | SLC1A2 (0.37) | HTTAPLNR | |
| SCHEMBL10943324 | 0.64 | — | — | |
| SCHEMBL18586584 | 0.61 | CYP3A4 (0.46) | HTTSMN1; SMN2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL24633711 | 0.61 | — | — | |
| SCHEMBL38655259 | 0.61 | — | — | |
| SCHEMBL11763607 | 0.60 | HTT (0.42) | HTT | |
| SCHEMBL10345485 | 0.60 | HTT (0.41) | HTTARG1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1207289-C | Metalloprotease inhibitors, pharmaceutical compositions containing them and their use as medicaments, process and intermediates for their preparation | AGOURON PHARMA (US) | 2005-06-22 | — | — | CN | disclosed |
| CN-1542002-A | Inhibitors of metalloproteinase, pharmaceutical compositions containing them, their pharmaceutical application and methods and intermediate compounds for their preparation | ������ҩ������˾ | 2004-11-03 | — | — | CN | disclosed |
| CN-1207734-A | Metalloprotease inhibitors, pharmaceutical compositions containing them and their use as medicaments, process and intermediates for their preparation | AGOURON PHARMA (US) | 1999-02-10 | — | — | CN | disclosed |