Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27661302 | 0.83 | ALDH1A1 (0.40) | KMT2AATMMEN1MAPK1L3MBTL1 | |
| SCHEMBL27841559 | 0.83 | MAPT (0.47) | KMT2AATMMEN1TSHRMAPK1 | |
| SCHEMBL28037760 | 0.82 | GRIA2 (0.41) | MAPK1NPC1MAPTALDH1A1POLB | |
| SCHEMBL7421292 | 0.81 | MAOB (0.52) | KMT2AMEN1TSHRL3MBTL1NPC1 | |
| SCHEMBL9815415 | 0.80 | HTT (0.51) | KMT2AMEN1MAPK1MAPTALDH1A1 | |
| SCHEMBL30435606 | 0.80 | HPD (0.45) | KMT2AMEN1MAPK1MAPTALDH1A1 | |
| SCHEMBL27654744 | 0.80 | S1PR4 (0.61) | KMT2AMEN1MAPK1NPC1RAB9A | |
| SCHEMBL3006053 | 0.78 | TSHR (0.51) | KMT2AATMMEN1TSHRMAPK1 | |
| SCHEMBL27585879 | 0.78 | MEN1 (0.50) | KMT2AMEN1TSHRMAPK1L3MBTL1 | |
| SCHEMBL310625 | 0.77 | TSHR (0.55) | KMT2AATMMEN1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1982308-B | Substituted pyrazoles | ORTHO MCNEIL PHARM INC | 2010-06-16 | — | — | CN | disclosed |
| CN-1982308-A | Substituted pyrazoles | ORTHO MCNEIL PHARM INC (US) | 2007-06-20 | — | — | CN | disclosed |
| CN-1294130-C | Substituted pyrazoles | ORTHO MCNEIL PHARM INC (US) | 2007-01-10 | — | — | CN | disclosed |
| CN-1212839-C | Use of substituted pyrazoles for the preparation of a medicament for the treatment of allergies | ORTHO MCNEIL PHARM INC (US) | 2005-08-03 | — | — | CN | disclosed |
| CN-1473043-A | A method for treating allergy by using substituted pyrazole | ����-������ҩƷ��˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1468237-A | Substituted pyrazoles | 奥索-麦克尼尔药品公司 | 2004-01-14 | — | — | CN | disclosed |