Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rasagiline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 8/20 | 0.95 |
| ▸ | MAOA | P21397 | 8/20 | 0.95 |
| ▸ | ACHE | P22303 | 10/20 | 0.83 |
| ▸ | BCHE | P06276 | 2/20 | 0.83 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.83 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.83 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rasagiline SCHEMBL2322409 | 1.00 | MAOA (0.95) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL29469725 | 0.97 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Azilect SCHEMBL5960892 | 0.97 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL5135147 | 0.97 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL158439 | 0.97 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2825094 | 0.97 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2553678 | 0.93 | MAOA (0.88) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL12787613 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2827373 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Azilect SCHEMBL29605291 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1096853-C | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof | TEVA PHARMA (NL) | 2002-12-25 | — | — | CN | disclosed |
| CN-1191481-A | R-enantiomer of N-propargyl-1-aminoindan, salts thereof and use of compositions | TEVA PHARMA (IL) | 1998-08-26 | — | — | CN | disclosed |