Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azilect. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 8/20 | 1.00 |
| ▸ | MAOA | P21397 | 8/20 | 1.00 |
| ▸ | ACHE | P22303 | 10/20 | 0.83 |
| ▸ | BCHE | P06276 | 2/20 | 0.83 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.83 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.83 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rasagiline SCHEMBL2825094 | 1.00 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL29469725 | 1.00 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL5135147 | 1.00 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL158439 | 1.00 | MAOA (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL27489652 | 0.97 | MAOA (0.95) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2322409 | 0.97 | MAOA (0.95) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2553678 | 0.93 | MAOA (0.88) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL12787613 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Rasagiline SCHEMBL2827373 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B | |
| Azilect SCHEMBL29605291 | 0.91 | MAOB (1.00) | MAOAMAOBACHEBCHEADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738149-B1 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 2006-11-29 | — | — | EP | disclosed |
| EP-0929298-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMA (IL) | 2006-06-07 | — | — | EP | disclosed |
| US-6528685-B2 | Such as (R)-N-(2-acetamido)-1-aminoindan for treatment of Parkinson's disease, dementia, epilepsy, convulsions, or seizures | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-03-04 | — | — | US | disclosed |
| US-6277886-B1 | ADMINISTERING TO TREAT SUBJECT SUFFERING FROM NEUROTRAUMA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2001-08-21 | — | — | US | disclosed |
| US-6271263-B1 | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2001-08-07 | — | — | US | disclosed |
| US-5994408-A | THERAPY FOR PARKINSON'S DISEASE; ANTICONVULSANT | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-11-30 | — | — | US | disclosed |
| EP-0738149-A4 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 1999-10-27 | — | — | EP | disclosed |
| EP-0929298-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-07-21 | — | — | EP | disclosed |
| US-5914349-A | ANTICONVULSANTS, EPILEPSY AND COGNITIVE AGENTS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-06-22 | — | — | US | disclosed |
| US-5880159-A | TREATING ACUTE NEUROLOGICAL TRAUMATIC DISORDER OR NEUROTRAUMA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-03-09 | — | — | US | disclosed |
| US-5877221-A | TREATING DEMENTIA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-03-02 | — | — | US | disclosed |
| US-5877218-A | PARKINSON'S DISEASE; ANTIEPILEPSY AGENTS; ANTICONVULSANTS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-03-02 | — | — | US | disclosed |
| WO-1998002152-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING S-(-)-N-PROPARGYL-1-AMINO INDAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1998-01-22 | — | — | WO | disclosed |
| US-5639913-A | TREATMENT OF PARKINSON'S DISEASE, DEMENTIA, EPILEPSY | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1997-06-17 | — | — | US | disclosed |
| EP-0738149-A1 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1996-10-23 | — | — | EP | disclosed |
| WO-1996021640-A1 | OPTICALLY ACTIVE AMINOINDANE DERIVATIVES AND PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1996-07-18 | — | — | WO | disclosed |
| WO-1995018617-A1 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1995-07-13 | — | — | WO | disclosed |