Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2413818 | 0.84 | MAPK1 (0.42) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL18103225 | 0.83 | LMNA (0.42) | MAPK1HTTLMNATP53ALDH1A1 | |
| SCHEMBL22409931 | 0.83 | ALDH1A1 (0.39) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL1569950 | 0.82 | MAPK1 (0.36) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL31705019 | 0.81 | LMNA (0.64) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL2698362 | 0.81 | PDE2A (0.55) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL22664912 | 0.81 | LMNA (0.64) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL9910111 | 0.81 | PDE2A (0.55) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL2004602 | 0.81 | LMNA (0.64) | MAPK1HTTLMNATP53TSHR | |
| SCHEMBL2502857 | 0.81 | PDE2A (0.55) | MAPK1HTTLMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596951-A | 8-ethyl-6-(aryl)pyrido [2,3-d]pyrimidin-7(8h)-ones for the treatment of nervous system disorders and cancer | AFRAXIS INC | 2014-02-19 | — | — | CN | disclosed |
| CN-101808992-B | 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives | HOFFMANN LA ROCHE | 2012-09-26 | — | — | CN | disclosed |
| CN-102648200-A | 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders | AFRAXIS INC | 2012-08-22 | — | — | CN | disclosed |
| CN-102348682-A | 1,1,1-trifluoro-2-hydroxypropyl compounds | HOFFMANN LA ROCHE | 2012-02-08 | — | — | CN | disclosed |
| CN-101538268-B | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER | 2011-07-27 | — | — | CN | disclosed |
| CN-101432262-B | Cyclohexyl-substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI | 2011-06-01 | — | — | CN | disclosed |
| CN-101808992-A | 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives | HOFFMANN LA ROCHE | 2010-08-18 | — | — | CN | disclosed |
| CN-101792436-A | Benzimidazole derivatives used in the treatment of diseases associated with vanilloid receptor 1 | ASTRAZENECA R & D SODERTALJE | 2010-08-04 | — | — | CN | disclosed |
| CN-101538268-A | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER | 2009-09-23 | — | — | CN | disclosed |
| CN-101522637-A | Benzimidazole derivatives useful for the treatment of vanilloid receptor 1-related disorders | ASTRAZENECA AB (SE) | 2009-09-02 | — | — | CN | disclosed |
| CN-1263751-C | Novel compounds | ASTRAZENECA AB (SE) | 2006-07-12 | — | — | CN | disclosed |
| CN-1729190-A | 3-phenyl-substituted pyridoindolones, their preparation and therapeutic use | SANOFI AVENTIS (FR) | 2006-02-01 | — | — | CN | disclosed |
| CN-1231465-C | Biphenylsulfonyl cyanamides, method for the production thereof and use thereof as medicaments | AVENTIS PHARMACEUTIC DEUTSCHLA (DE) | 2005-12-14 | — | — | CN | disclosed |
| CN-1211370-C | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| CN-1617856-A | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them | AVENTIS PHARMA GMBH (DE) | 2005-05-18 | — | — | CN | disclosed |
| CN-1176911-C | Benzidine-sulfuryl radical substitution pentatomic heterocycle, its preparation method, its medicinal and composition | �ճ�˹�عɷݹ�˾ | 2004-11-24 | — | — | CN | disclosed |
| CN-1541214-A | Novel compounds | — | 2004-10-27 | — | — | CN | disclosed |
| CN-1309645-A | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2001-08-22 | — | — | CN | disclosed |
| CN-1289321-A | Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament | AVENTIS PHARMACEUTIC DEUTSCHLA (DE) | 2001-03-28 | — | — | CN | disclosed |
| CN-1188760-A | Benzidine-sulfuryl radical substitution pentatomic heterocycle, its preparation method, its medicinal and composition | HOECHST AG (DE) | 1998-07-29 | — | — | CN | disclosed |