Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.58 |
| ▸ | EGFR | P00533 | 15/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163877 | 0.83 | EGFR (0.56) | CSF1REGFRPDGFRBPDGFRAKDM4E | |
| SCHEMBL6181964 | 0.81 | EGFR (0.77) | CSF1REGFRPDGFRBPDGFRAKDM4E | |
| Hydrochloric Acid SCHEMBL6182000 | 0.81 | EGFR (0.78) | CSF1REGFRPDGFRBPDGFRAKDM4E | |
| SCHEMBL4726476 | 0.78 | CSF1R (0.64) | CSF1REGFRPDGFRBPDGFRAKDM4E | |
| SCHEMBL16376059 | 0.76 | EGFR (0.57) | CSF1REGFR | |
| SCHEMBL8261880 | 0.76 | CSF1R (0.64) | CSF1REGFRPDGFRBPDGFRAHTT | |
| SCHEMBL5618017 | 0.75 | CSF1R (0.64) | CSF1REGFRPDGFRBPDGFRAKDM4E | |
| Hydrochloric Acid SCHEMBL8518306 | 0.74 | CSF1R (0.65) | CSF1REGFRPDGFRBPDGFRAHTT | |
| SCHEMBL2257706 | 0.74 | CSF1R (1.00) | CSF1REGFRPDGFRBPDGFRARET | |
| SCHEMBL8177845 | 0.73 | EGFR (1.00) | CSF1REGFRPDGFRBPDGFRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | disclosed |