Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.77 |
| ▸ | CSF1R | P07333 | 13/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6182000 | 0.99 | EGFR (0.78) | EGFRCSF1RPDGFRBPDGFRAKDM4E | |
| SCHEMBL8177845 | 0.87 | EGFR (1.00) | EGFRCSF1RPDGFRBPDGFRAKDM4E | |
| Hydrochloric Acid SCHEMBL6181342 | 0.86 | EGFR (1.00) | EGFRCSF1RPDGFRBPDGFRARET | |
| Hydrochloric Acid SCHEMBL8811425 | 0.83 | EGFR (0.93) | EGFRCSF1RPDGFRBPDGFRARET | |
| SCHEMBL27490671 | 0.81 | CSF1R (0.58) | EGFRCSF1RPDGFRBPDGFRAKDM4E | |
| SCHEMBL5618017 | 0.81 | CSF1R (0.64) | EGFRCSF1RPDGFRBPDGFRAKDM4E | |
| SCHEMBL2257706 | 0.80 | CSF1R (1.00) | EGFRCSF1RPDGFRBPDGFRARET | |
| Hydrochloric Acid SCHEMBL6179746 | 0.79 | CSF1R (1.00) | EGFRCSF1RPDGFRBPDGFRARET | |
| SCHEMBL4726476 | 0.79 | CSF1R (0.64) | EGFRCSF1RPDGFRBPDGFRAKDM4E | |
| SCHEMBL4741361 | 0.78 | EGFR (0.82) | EGFRCSF1RPDGFRBPDGFRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871448-B1 | ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2005-03-02 | — | — | EP | claimed |
| CN-1100540-C | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | AVENTIS PHARMA INC (US) | 2003-02-05 | — | — | CN | claimed |
| US-RE37650-E1 | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase | AVENTIS PHARMACETICAL PRODUCTS, INC. | 2002-04-09 | — | — | US | claimed |
| CN-1187129-A | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | RHONE POULENC RORER PHARMA (US) | 1998-07-08 | — | — | CN | claimed |
| EP-0831831-A4 | PROTEIN TYROSINE KINASE ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS HAVING SELECTIVE INHIBITION OF HER-2 AUTOPHOSPHORYLATION PROPERTIES | RHONE POULENC RORER PHARMA (US) | 1998-05-27 | — | — | EP | claimed |
| EP-0831831-A1 | PROTEIN TYROSINE KINASE ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS HAVING SELECTIVE INHIBITION OF HER-2 AUTOPHOSPHORYLATION PROPERTIES | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1998-04-01 | — | — | EP | claimed |
| US-5721237-A | ADMINISTERING FOR THE SELECTIVE TREATMENT OF CELL GROWTH AND DIFFERENTIATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-24 | — | — | US | claimed |
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |
| WO-1996039145-A1 | PROTEIN TYROSINE KINASE ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS HAVING SELECTIVE INHIBITION OF HER-2 AUTOPHOSPHORYLATION PROPERTIES | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-12-12 | — | — | WO | claimed |
| CN-1100540-C | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | AVENTIS PHARMA INC (US) | 2003-02-05 | — | — | CN | disclosed |
| CN-1187129-A | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | RHONE POULENC RORER PHARMA (US) | 1998-07-08 | — | — | CN | disclosed |