Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 4/20 | 0.34 |
| ▸ | MMP13 | P45452 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | BMP1 | P13497 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPOR | P19235 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655796 | 0.81 | KEAP1 (0.56) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| Anisole SCHEMBL27491725 | 0.81 | KEAP1 (0.38) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| SCHEMBL6608765 | 0.74 | KEAP1 (0.64) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| SCHEMBL8023076 | 0.73 | KEAP1 (0.46) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| SCHEMBL6628304 | 0.72 | KMT2A (0.44) | KEAP1NFE2L2ATMEPOR | |
| SCHEMBL6614754 | 0.72 | KMT2A (0.44) | KEAP1NFE2L2ATMEPOR | |
| SCHEMBL6614758 | 0.72 | KMT2A (0.44) | KEAP1NFE2L2ATMEPOR | |
| SCHEMBL7389789 | 0.71 | KEAP1 (0.44) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| SCHEMBL6610164 | 0.69 | BMP1 (0.48) | KEAP1NFE2L2MMP8MMP13MMP2 | |
| SCHEMBL27537682 | 0.68 | TSHR (0.39) | MMP8MMP13MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1197849-C | 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2005-04-20 | — | — | CN | disclosed |
| CN-1337952-A | 2,3,4, 5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2002-02-27 | — | — | CN | disclosed |