Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6340430 | 0.98 | MAOB (0.33) | MPOMAOBALDH1A1LMNATDP1 | |
| SCHEMBL6330210 | 0.82 | MPO (0.34) | MPOALDH1A1LMNATDP1ALOX15 | |
| SCHEMBL2648560 | 0.75 | — | — | |
| SCHEMBL406366 | 0.69 | HCAR3 (0.37) | MPOMAOBALDH1A1LMNATDP1 | |
| Hydrochloric Acid SCHEMBL941062 | 0.69 | — | — | |
| SCHEMBL25619105 | 0.68 | MAPK1 (0.32) | MPOALDH1A1MAPK1 | |
| SCHEMBL15703047 | 0.66 | MEN1 (0.39) | MPOMAOBALDH1A1LMNATDP1 | |
| SCHEMBL25864888 | 0.65 | CNR2 (0.31) | — | |
| SCHEMBL15882053 | 0.64 | MAOB (0.36) | MPOMAOBALDH1A1LMNATDP1 | |
| SCHEMBL22363263 | 0.64 | LRRK2 (0.41) | MPOMAOBALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281588-C | Novel intermediate for prepn. of pyrazolopyrimidinones | PFIZER (US) | 2006-10-25 | — | — | CN | disclosed |
| CN-1626516-A | Novel intermediate for prepn. of pyrazolopyrimidinones | PFIZER (US) | 2005-06-15 | — | — | CN | disclosed |
| CN-1188415-C | Pyrazolopyrimidinones inhibiting type 5 cyclic guanosine 3',5' -monophosphate phosphodiesterase (cG MP PDE5) for the treatment of sexual dysfunction | PFIZER LTD (US) | 2005-02-09 | — | — | CN | disclosed |
| CN-1253561-A | Pyrazolopyrimidinones inhibiting type 5 cyclic guanosine 3',5' -monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction | PFIZER LTD (US) | 2000-05-17 | — | — | CN | disclosed |