Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | TSHR | P16473 | 4/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL1310130 | 0.97 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL4947587 | 0.97 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL3708713 | 0.97 | — | — | |
| Acrylamide SCHEMBL28418599 | 0.94 | ALDH1A1 (0.69) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL9936680 | 0.94 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL35469 | 0.94 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL9304706 | 0.94 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL679118 | 0.94 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL843143 | 0.94 | — | — | |
| Acrylic Acid SCHEMBL19876598 | 0.91 | TSHR (0.65) | ALDH1A1TSHRFGFR4LMNAFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1214292-C | Forming method for photoresist design and its laminating products | TOKYO OKA GOGYO K K (JP) | 2005-08-10 | — | — | CN | disclosed |
| CN-1424626-A | Forming method for photoresist design and its laminating products | TOKYO OKA GOGYO K K (JP) | 2003-06-18 | — | — | CN | disclosed |