Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL1310130 | 1.00 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL3708713 | 1.00 | — | — | |
| Acrylamide SCHEMBL28418599 | 0.97 | ALDH1A1 (0.69) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL27497451 | 0.97 | ALDH1A1 (0.69) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL27674970 | 0.91 | ALDH1A1 (0.61) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL27525186 | 0.91 | ALDH1A1 (0.61) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL3392716 | 0.90 | — | — | |
| Acrylamide SCHEMBL679118 | 0.90 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL35469 | 0.90 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 | |
| Acrylamide SCHEMBL9936680 | 0.90 | ALDH1A1 (0.79) | ALDH1A1TSHRFGFR4LMNAFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112384222-B | Exon-skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117298290-A | Exon-skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-110337308-B | Exon-skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-110290812-B | Exon-skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112384222-A | Exon skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-110636866-A | Exon skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2019-12-31 | — | — | CN | disclosed |
| CN-110337308-A | exon skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2019-10-15 | — | — | CN | disclosed |
| CN-110290812-A | exon skipping oligomer conjugates for muscular dystrophy | 萨勒普塔医疗公司 | 2019-09-27 | — | — | CN | disclosed |
| US-20150204815-A1 | LIQUID PROTEIN MARKERS FOR NATIVE GEL ELECTROPHORESIS | Life Technologies Corporation | 2015-07-23 | — | — | US | disclosed |
| EP-1898938-A2 | LIQUID PROTEIN MARKERS FOR NATIVE GEL ELECTROPHORESIS | INVITROGEN CORPORATION (US) | 2008-03-19 | — | — | EP | disclosed |
| US-20070026479-A1 | Liquid protein markers for native gel electrophoresis | INVITROGEN CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |
| WO-2007002676-A2 | LIQUID PROTEIN MARKERS FOR NATIVE GEL ELECTROPHORESIS | INVITROGEN CORPORATION (US) | 2007-01-04 | — | — | WO | disclosed |