Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27751325 | 0.97 | TSHR (0.55) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Maleic Acid SCHEMBL27502549 | 0.97 | TSHR (0.55) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Maleic Acid SCHEMBL27579369 | 0.97 | TSHR (0.55) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Maleic Acid SCHEMBL27640241 | 0.85 | HCAR2 (0.44) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Chlorobenzene SCHEMBL27620795 | 0.83 | TSHR (0.73) | TSHRCES2CES1MAOBCYP1B1 | |
| Chlorobenzene SCHEMBL2533883 | 0.83 | TSHR (0.73) | TSHRCES2CES1MAOBCYP1B1 | |
| Chlorobenzene SCHEMBL29172530 | 0.83 | TSHR (0.73) | TSHRCES2CES1MAOBCYP1B1 | |
| Chlorobenzene SCHEMBL27335147 | 0.82 | TSHR (0.55) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Chlorobenzene SCHEMBL28122241 | 0.82 | TSHR (0.55) | TSHRHCAR2HDAC3TNKSHDAC4 | |
| Chlorobenzene SCHEMBL16894006 | 0.80 | TSHR (0.69) | TSHRCES2CES1MAOBCYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108904452-A | A kind of preparation method of pediatric paracetamol granule | 康美保宁（四川）制药有限公司 | 2018-11-30 | — | — | CN | claimed |
| CN-107884503-A | 22 kinds of detection methods for illegally adding relieving cough and asthma class medicine in asthma-relieving bolus of gecko | 广西壮族自治区食品药品检验所 | 2018-04-06 | — | — | CN | claimed |
| CN-106511969-A | A composite medicinal preparation used for treating gout and a preparing method thereof | 南京汉尔斯生物科技有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-106324162-A | High performance liquid chromatography-time-of-flight mass spectrometry method for identifying degradation product in compound cold treatment medicine based on heart-cutting technology | 深圳海王药业有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-109876122-A | A kind of curing cold capsule and preparation method thereof | 广东一力集团制药股份有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-109568333-A | A kind of nasal drops and preparation method thereof for treating rhinitis | 江西润泽药业有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-109464467-A | A kind of paracetamol caffein atificial cow-bezoar and preparation method thereof with slow releasing function | 安徽东盛友邦制药有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109453177-A | A kind of broad-spectrum antiseptic antiallergy anti-inflammation analgesic | 张华勇 | 2019-03-12 | — | — | CN | disclosed |
| CN-106045901-B | The chiral separation method and compound paracetamol and amantadine hydrochloride preparations of chlorphenamine | 吉林省吴太感康药业有限公司 | 2019-02-26 | — | — | CN | disclosed |
| CN-109310646-A | Delivery-enhancing epinephrine compositions | 阿奎斯蒂弗医疗股份有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-109310647-A | Pharmaceutical composition with enhanced penetration | 阿奎斯蒂弗医疗股份有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-108931586-A | A kind of compound codeine phosphate oral administration solution measuring method | 青海省药品检验检测院 | 2018-12-04 | — | — | CN | disclosed |
| CN-1476325-B | Delivery system for active substances and method for protecting and administering active substances | SHIRE LLC | 2012-09-05 | — | — | CN | disclosed |
| CN-101869713-A | The induction system of active substance and the protection of active substance and application process | SHIRE LLC (US) | 2010-10-27 | — | — | CN | disclosed |
| CN-101332157-A | Cysteine derivatives | AJINOMOTO KK (JP) | 2008-12-31 | — | — | CN | disclosed |
| CN-1935227-A | Medicine composition for improving sleep | SSP CO LTD (JP) | 2007-03-28 | — | — | CN | disclosed |
| CN-1499960-A | Chornotherapeutic dosage forms | ����˹��ҩ�﹫˾ | 2004-05-26 | — | — | CN | disclosed |
| CN-1476325-A | Delivery system for active substances and method for protecting and administering active substances | 新河药品股份有限公司 | 2004-02-18 | — | — | CN | disclosed |
| CN-1330516-A | Improved of chewing gum containing medicament active agents release | WRIGLEY W M JUN CO (US) | 2002-01-09 | — | — | CN | disclosed |
| CN-1231181-A | New usage for Ganmaotong (Common cold medicine) | SUN YUHUAN (CN) | 1999-10-13 | — | — | CN | disclosed |