Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 13/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 13/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 12/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15858027 | 1.00 | ADRA2A (0.52) | ADRA2AADRA2CADRA2BLMNAALDH1A1 | |
| SCHEMBL15383525 | 1.00 | ADRA2A (0.52) | ADRA2AADRA2CADRA2BLMNAALDH1A1 | |
| SCHEMBL30720288 | 0.91 | TP53 (0.47) | ADRA2AADRA2CADRA2BLMNAALDH1A1 | |
| SCHEMBL17898055 | 0.84 | ADRA2A (0.52) | ADRA2AADRA2CADRA2B | |
| SCHEMBL10293570 | 0.84 | ADRA2A (0.52) | ADRA2AADRA2CADRA2B | |
| SCHEMBL81498 | 0.84 | ADRA2A (0.52) | ADRA2AADRA2CADRA2B | |
| SCHEMBL24518340 | 0.82 | CDK4 (0.47) | ADRA2AADRA2CADRA2B | |
| SCHEMBL15858055 | 0.82 | ADRA2A (0.52) | ADRA2AADRA2CADRA2BNOTUMKDM4E | |
| SCHEMBL29964416 | 0.82 | ADRA2A (0.44) | ADRA2AADRA2CADRA2B | |
| SCHEMBL188069 | 0.82 | ADRA2C (0.56) | ADRA2AADRA2CADRA2BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183119-C | Arylpiperzines as metalloproteinase inhibiting agents (MMP) and their use | — | 2005-01-05 | — | — | CN | disclosed |