Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 9/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476915 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL519022 | 0.89 | KMT2A (0.46) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL519023 | 0.89 | KMT2A (0.46) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL2474934 | 0.88 | KMT2A (0.44) | ALDH1A1KMT2APOLBGAARXFP1 | |
| SCHEMBL2749640 | 0.88 | KMT2A (0.44) | ALDH1A1KMT2APOLBGAARXFP1 | |
| SCHEMBL2501205 | 0.84 | KDM4E (0.44) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL2501209 | 0.84 | KDM4E (0.44) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL7901314 | 0.83 | KMT2A (0.46) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL518426 | 0.83 | KMT2A (0.59) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 | |
| SCHEMBL518427 | 0.83 | KMT2A (0.59) | ALDH1A1KMT2APOLBKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | disclosed |
| US-8178538-B2 | Pyridazinones | HOFFMANN-LA ROCHE INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100152193-A1 | PYRIDAZINONES | HOFFMANN-LA ROCHE, INC. | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152193-A1 | PYRIDAZINONES | PDE5A, PDE3A, PDE10A | ALDH1A1 251/4885KMT2A 2667/4885POLB 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.