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SCHEMBL27503556

SCHEMBL27503556

COc1ccc(S(=O)(=O)N(CCC(=O)N2CCN(OC(C)=O)CC2)C(C(=O)NO)C(C)C)cc1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 12/20 0.57
▸ MMP8 P22894 11/20 0.57
▸ MMP13 P45452 10/20 0.57
▸ MMP9 P14780 10/20 0.57
▸ BMP1 P13497 6/20 0.53
▸ MMP1 P03956 2/20 0.53
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48
▸ CA9 Q16790 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6438866 0.89 MMP2 (0.60) MMP2MMP8MMP13MMP9BMP1
SCHEMBL27540117 0.86 BMP1 (0.60) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8011113 0.86 MMP2 (0.55) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8016814 0.86 MMP2 (0.57) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8019045 0.86 MMP2 (0.57) MMP2MMP8MMP13MMP9BMP1
Hydrochloric Acid SCHEMBL27543837 0.86 MMP2 (0.58) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8012982 0.86 MMP2 (0.61) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8015460 0.84 MMP2 (0.55) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8015005 0.84 MMP2 (0.55) MMP2MMP8MMP13MMP9BMP1
SCHEMBL8015392 0.84 MMP2 (0.57) MMP2MMP8MMP13MMP9BMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1228083-A Arylsulfonylamino hydroxamic acid derivatives PFIZER (US) 1999-09-08 — — CN disclosed