Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834259 | 0.83 | SLC2A1 (0.56) | ALDH1A1KDM4EHPGDDRD2DRD4 | |
| SCHEMBL11420544 | 0.83 | HSD17B10 (0.67) | HSD17B10ALDH1A1KDM4ETDP1CYP3A4 | |
| SCHEMBL29131708 | 0.81 | TDP1 (0.61) | HSD17B10ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL27917034 | 0.80 | CYP3A4 (0.71) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9477688 | 0.80 | SLC2A1 (0.54) | ALDH1A1KDM4EHPGDDRD2DRD4 | |
| SCHEMBL28611348 | 0.80 | HSD17B10 (0.62) | HSD17B10ALDH1A1KDM4ETDP1CYP3A4 | |
| SCHEMBL27378135 | 0.79 | TDP1 (0.56) | HSD17B10ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL30975093 | 0.78 | PDE4A (0.64) | ALDH1A1KDM4EHPGDDRD2DRD4 | |
| SCHEMBL155982 | 0.78 | HSD17B10 (0.61) | HSD17B10MEN1KMT2ATSHRPOLB | |
| SCHEMBL30975091 | 0.78 | PDE4A (0.64) | ALDH1A1KDM4EHPGDDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |