Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.39 |
| ▸ | UGCG | Q16739 | 2/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27502193 | 0.90 | MAOB (0.42) | KDM4EALDH1A1LMNANPC1RAB9A | |
| Tert-Butyl Formate SCHEMBL27489233 | 0.87 | REN (0.59) | REN | |
| SCHEMBL6957567 | 0.80 | REN (0.45) | RENKDM4EALDH1A1LMNAS1PR1 | |
| SCHEMBL6043150 | 0.79 | REN (0.51) | RENKDM4EALDH1A1LMNAGBA1 | |
| SCHEMBL6043145 | 0.79 | REN (0.51) | RENKDM4EALDH1A1LMNAGBA1 | |
| SCHEMBL6951449 | 0.78 | REN (0.49) | RENKDM4EALDH1A1LMNAGBA1 | |
| SCHEMBL7447624 | 0.77 | REN (0.46) | RENKDM4EALDH1A1LMNANPC1 | |
| Tert-Butyl Formate SCHEMBL27529789 | 0.76 | TDP1 (0.36) | — | |
| SCHEMBL6955012 | 0.74 | REN (0.41) | RENKDM4EALDH1A1LMNAGBA1 | |
| SCHEMBL6626123 | 0.74 | REN (0.47) | RENL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |