Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042271 | 0.81 | KDM4E (0.44) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6043090 | 0.79 | REN (0.41) | RENKDM4EALDH1A1LMNALTA4H | |
| Tert-Butyl Formate SCHEMBL27504348 | 0.77 | REN (0.45) | RENKDM4EALDH1A1LMNALTA4H | |
| SCHEMBL6954184 | 0.76 | KDM4E (0.39) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6042268 | 0.75 | REN (0.45) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6043150 | 0.74 | REN (0.51) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6043145 | 0.74 | REN (0.51) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6951449 | 0.73 | REN (0.49) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6044047 | 0.73 | REN (0.45) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7591191 | 0.73 | REN (0.45) | RENKDM4EALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |