Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27480883 | 0.90 | HDAC8 (0.51) | HDAC8HDAC6HDAC1GRIA4GRIA2 | |
| SCHEMBL27466722 | 0.77 | HDAC8 (0.48) | HDAC8HDAC6HDAC1 | |
| SCHEMBL27466732 | 0.71 | HDAC8 (0.41) | HDAC8HDAC6HDAC1SLC6A3SLC6A4 | |
| SCHEMBL27466731 | 0.71 | HDAC8 (0.40) | HDAC8HDAC6HDAC1SLC6A3SLC6A4 | |
| SCHEMBL27506678 | 0.70 | MAOB (0.47) | LMNACHRNB2CHRNA7CHRNA4KMT2A | |
| SCHEMBL27482758 | 0.68 | MDM2 (0.41) | HDAC8HDAC6HDAC1ALDH1A1SLC6A3 | |
| SCHEMBL27483135 | 0.68 | HDAC8 (0.41) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27515302 | 0.68 | HDAC8 (0.41) | HDAC8HDAC6HDAC1MAPTLMNA | |
| SCHEMBL31195027 | 0.64 | HDAC8 (0.39) | HDAC8HDAC6HDAC1GRIA4GRIA2 | |
| SCHEMBL31195005 | 0.64 | HDAC8 (0.39) | HDAC8HDAC6HDAC1GRIA4GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |