Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 10/20 | 0.41 |
| ▸ | TP53 | P04637 | 9/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467155 | 0.88 | MDM2 (0.40) | MDM2TP53HTR2AHTR2CHTR2B | |
| SCHEMBL27466722 | 0.85 | HDAC8 (0.48) | HDAC8HDAC6HDAC1 | |
| SCHEMBL27466734 | 0.78 | HDAC8 (0.38) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27466725 | 0.78 | KMT2A (0.45) | MDM2ALDH1A1HDAC8HDAC6HDAC1 | |
| SCHEMBL27466733 | 0.78 | HDAC8 (0.38) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27480883 | 0.77 | HDAC8 (0.51) | ALDH1A1HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27466732 | 0.74 | HDAC8 (0.41) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27504948 | 0.74 | HDAC8 (0.38) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27483135 | 0.72 | HDAC8 (0.41) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL9781187 | 0.72 | HTR2A (0.55) | MDM2TP53HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |