Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Oleamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.59 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.59 |
| ▸ | FAAH | O00519 | 4/20 | 0.82 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | TERT | O14746 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | PPARA | Q07869 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oleamide SCHEMBL27510470 | 1.00 | FAAH (0.82) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL3177810 | 0.98 | FAAH (0.85) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL27552866 | 0.98 | FAAH (0.85) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL27721751 | 0.96 | FAAH (0.82) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL30525722 | 0.93 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Ammonia Solution, Strong SCHEMBL8466380 | 0.93 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL9983275 | 0.93 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL27961302 | 0.91 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL23528231 | 0.91 | FAAH (1.00) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| SCHEMBL21501560 | 0.91 | FAAH (1.00) | FAAHSOAT1CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1207965-C | Use of amine compounds with improved biodegradability as adjuvants for pesticides and fertilisers | AKZO NOBEL NV (NL) | 2005-06-29 | — | — | CN | disclosed |
| CN-1436042-A | Use of amine compounds with improved biodegradability as adjuvants for pesticides and fertilisers | AKZO NOBEL NV (NL) | 2003-08-13 | — | — | CN | disclosed |