Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5064884 | 0.84 | ALDH1A1 (0.60) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL29054131 | 0.82 | ALDH1A1 (0.58) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL22188511 | 0.82 | LMNA (0.50) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL22188536 | 0.80 | LMNA (0.48) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL28180936 | 0.79 | LMNA (0.48) | LMNAKDM4EALDH1A1 | |
| SCHEMBL542553 | 0.78 | HTR2A (0.56) | MEN1KMT2AALDH1A1 | |
| Citric Acid SCHEMBL31512993 | 0.78 | ALDH1A1 (0.52) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL27610202 | 0.77 | ALDH1A1 (0.56) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL21145049 | 0.77 | ALDH1A1 (0.60) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL21145048 | 0.77 | ALDH1A1 (0.60) | LMNAKDM4EMEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1265648-A | Conjugaes of dithiocarbamates with pharmacologically active agents and uses therefor | MEDINOX INC (US) | 2000-09-06 | — | — | CN | disclosed |