Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.43 |
| ▸ | FPR2 | P25090 | 6/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15742209 | 0.80 | FDPS (0.43) | CYP17A1ATRNAMPTBRD4MAPK14 | |
| SCHEMBL24509637 | 0.79 | CYP17A1 (0.39) | CYP17A1FPR2ATRSREBF2BRD4 | |
| SCHEMBL3978481 | 0.79 | MC1R (0.41) | CYP17A1FPR2ATRPTGDR2 | |
| SCHEMBL26086457 | 0.79 | BRD4 (0.39) | CYP17A1ATRBRD4MAPKAPK2PTGDR2 | |
| SCHEMBL13326810 | 0.78 | ATR (0.40) | CYP17A1ATRNAMPTBRD4 | |
| SCHEMBL29264728 | 0.76 | CYP17A1 (0.36) | CYP17A1FPR2ATRSREBF2BRD4 | |
| SCHEMBL15264820 | 0.72 | ATR (0.48) | CYP17A1ATRNAMPT | |
| SCHEMBL1029793 | 0.71 | KDM4E (0.49) | CYP17A1ATRNAMPT | |
| SCHEMBL24510120 | 0.70 | MAPT (0.35) | FPR2BRD4 | |
| SCHEMBL28230449 | 0.70 | ALDH1A1 (0.43) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1237060-C | Quinzolone derivatives as alpha IA/B adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | disclosed |
| CN-1484640-A | Quinazolinone derivatives as alpha 1A/B adrenergic receptor antagonists | - | 2004-03-24 | — | — | CN | disclosed |