Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
| ▸ | DBH | P09172 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15804049 | 0.78 | BRD4 (0.54) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL27913383 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL27838313 | 0.74 | HDAC8 (0.61) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL8878870 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL3195921 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL23612119 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL27700003 | 0.72 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL27944822 | 0.72 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL28110914 | 0.72 | CYP11B1 (0.55) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 | |
| SCHEMBL14817322 | 0.72 | KDM4E (0.71) | ALDH1A1KDM4EL3MBTL1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104761557-B | Hexahydro-1H-pyrrolo[3,4-d]pyrimidine compound and preparation method thereof | 河南师范大学 | 2017-02-22 | — | — | CN | disclosed |
| CN-101168528-B | Method for synthesizing 3-aminopyrrolidine and dihydrochloride thereof | CHIFENG WANZE PHARMACY CO LTD | 2011-10-05 | — | — | CN | disclosed |
| CN-1922139-B | Bicyclic amide derivatives | KYORIN SEIYAKU KK | 2010-12-29 | — | — | CN | disclosed |
| CN-1922139-A | Bicyclic amide derivatives | KYORIN SEIYAKU KK (JP) | 2007-02-28 | — | — | CN | disclosed |
| CN-1518450-A | Use of adenosine analogues for the preparation of a medicament for the treatment of insulin resistance syndrome and diabetes | ���ĵ�˹ҩ��¹�����˾ | 2004-08-04 | — | — | CN | disclosed |
| CN-1228770-A | Compounds with antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties | RHONE POULENC RORER PHARMA (US) | 1999-09-15 | — | — | CN | disclosed |