Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 13/20 | 0.62 |
| ▸ | FOLR1 | P15328 | 11/20 | 0.56 |
| ▸ | SLC46A1 | Q96NT5 | 8/20 | 0.56 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.56 |
| ▸ | FOLR2 | P14207 | 4/20 | 0.56 |
| ▸ | ATIC | P31939 | 5/20 | 0.55 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.52 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065440 | 1.00 | GART (0.62) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL6829597 | 1.00 | GART (0.62) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL20659947 | 1.00 | GART (0.62) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL1065450 | 1.00 | GART (0.62) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL7745908 | 0.88 | GART (0.75) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| Lometrexol SCHEMBL18530 | 0.85 | GART (0.78) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| Lometrexol SCHEMBL21248426 | 0.85 | GART (0.77) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL9380609 | 0.82 | DHFR (0.59) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL9383067 | 0.82 | DHFR (0.59) | GARTFOLR1SLC46A1SLC19A1FOLR2 | |
| SCHEMBL9381796 | 0.82 | DHFR (0.59) | GARTFOLR1SLC46A1SLC19A1FOLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1290247-A | Process and intermediates for the preparation of antifolates | LILLY CO ELI (US) | 2001-04-04 | — | — | CN | disclosed |