Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.70 |
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11431700 | 0.93 | RAB9A (0.60) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL25993053 | 0.84 | EPHX2 (0.67) | RAB9ANPC1EPHX1SMN1; SMN2EPHX2 | |
| SCHEMBL2751880 | 0.84 | RAB9A (0.97) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL10144126 | 0.83 | NPC1 (0.72) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL15975491 | 0.83 | RAB9A (1.00) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL2750450 | 0.83 | EPHX1 (0.97) | RAB9ANPC1EPHX1GAASMN1; SMN2 | |
| SCHEMBL10211642 | 0.82 | NPC1 (0.51) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL21779872 | 0.81 | NPC1 (0.49) | RAB9ANPC1EPHX1LMNANPSR1 | |
| SCHEMBL813709 | 0.81 | EPHX1 (1.00) | RAB9ANPC1EPHX1GAASMN1; SMN2 | |
| SCHEMBL2751970 | 0.81 | EPHX1 (0.69) | RAB9ANPC1EPHX1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178570-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20060293342-A1 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293342-A1 | Tie-2 modulators and methods of use | TIE1, TEK, KDR | RAB9A 3880/4885NPC1 4467/4885EPHX1 1178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.