Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11431700 | 0.84 | RAB9A (0.60) | NPC1RAB9AMEN1KMT2AEPHX1 | |
| SCHEMBL2753005 | 0.81 | RAB9A (0.70) | NPC1RAB9AMEN1KMT2AEPHX1 | |
| SCHEMBL24342377 | 0.76 | EPHX2 (0.65) | RAB9AKMT2AEPHX1GAATP53 | |
| SCHEMBL27923493 | 0.75 | MEN1 (0.73) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL21779850 | 0.75 | ALDH1A1 (0.50) | NPC1RAB9AMEN1KMT2AEPHX1 | |
| SCHEMBL26087834 | 0.72 | LMNA (0.55) | RAB9AMEN1KMT2ANPSR1LMNA | |
| SCHEMBL10211642 | 0.72 | NPC1 (0.51) | NPC1RAB9AEPHX1NPSR1LMNA | |
| SCHEMBL13756245 | 0.70 | MEN1 (0.85) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL15695581 | 0.70 | MEN1 (0.60) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL17410626 | 0.69 | NPC1 (0.86) | NPC1RAB9AMEN1KMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3616753-A1 | COMPOUNDS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | Corvus Pharmaceuticals, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |