Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656810 | 0.82 | DPP4 (0.45) | TYK2JAK2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4767580 | 0.81 | PIM1 (0.37) | TYK2JAK2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL3342272 | 0.80 | ALDH1A1 (0.41) | TYK2JAK2JAK1ALDH1A1RAB9A | |
| SCHEMBL382884 | 0.80 | TYK2 (0.39) | TYK2JAK2JAK1ALDH1A1THRB | |
| SCHEMBL30765091 | 0.80 | TYK2 (0.39) | TYK2JAK2JAK1ALDH1A1THRB | |
| SCHEMBL16414368 | 0.80 | ALDH1A1 (0.36) | ALDH1A1THRBSMN1; SMN2KDM4ECSNK1A1 | |
| SCHEMBL25932246 | 0.78 | CSNK1A1 (0.36) | ALDH1A1THRBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28964614 | 0.76 | ATR (0.41) | ALDH1A1LMNAKMT2A | |
| SCHEMBL844466 | 0.76 | CA12 (0.45) | ALDH1A1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL27574983 | 0.76 | CA12 (0.39) | ALDH1A1THRBSMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |