Sugi Predict

Sugi Predict / Compounds / SCHEMBL382884

SCHEMBL382884

SCHEMBL382884

CC(=O)c1c(Cl)ccnc1Cl

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 7/20 0.39
▸ JAK2 O60674 5/20 0.39
▸ JAK1 P23458 4/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.36
▸ PTGES O14684 1/20 0.36
▸ SLC6A9 P48067 1/20 0.36
▸ THRB P10828 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ GAA P10253 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ DPP4 P27487 1/20 0.33
▸ CSNK1A1 P48729 1/20 0.33
▸ CSNK1D P48730 1/20 0.33
▸ CLK2 P49760 1/20 0.33
▸ CSNK1G1 Q9HCP0 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30765091 1.00 TYK2 (0.39) TYK2JAK2JAK1SMN1; SMN2LMNA
SCHEMBL17692459 0.82 SMN1; SMN2 (0.37) TYK2SMN1; SMN2LMNAALDH1A1THRB
SCHEMBL31713567 0.81 SMN1; SMN2 (0.48) TYK2JAK2SMN1; SMN2LMNAALDH1A1
SCHEMBL3223703 0.81 ALDH1A1 (0.52) TYK2JAK2JAK1SMN1; SMN2LMNA
SCHEMBL392396 0.81 SMN1; SMN2 (0.48) TYK2JAK2SMN1; SMN2LMNAALDH1A1
SCHEMBL31713579 0.81 ALDH1A1 (0.52) TYK2JAK2JAK1SMN1; SMN2LMNA
SCHEMBL31146087 0.80 HSD17B10 (0.38) TYK2JAK2JAK1SMN1; SMN2LMNA
SCHEMBL27532136 0.80 TYK2 (0.37) TYK2JAK2JAK1SMN1; SMN2LMNA
SCHEMBL16995132 0.80 LMNA (0.36) TYK2JAK2JAK1SMN1; SMN2LMNA
Hydrochloric Acid SCHEMBL9355662 0.79 SMN1; SMN2 (0.47) TYK2JAK2SMN1; SMN2LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250092009-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD (AU) 2025-03-20 — — US disclosed
CN-112424181-B Substituted condensed thiophenes as STING modulators 希泰克斯特私人有限公司 2024-02-27 — — CN disclosed
EP-4308122-A1 HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2024-01-24 — — EP disclosed
EP-3793988-B1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD (AU) 2023-11-15 — — EP disclosed
US-20230227423-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD (AU) 2023-07-20 — — US disclosed
US-20230227423-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD (AU) 2023-07-20 — — US disclosed
US-20230227423-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD (AU) 2023-07-20 — — US disclosed
US-11613525-B2 Substituted condensed thiophenes as modulators of sting CTXT PTY LIMITED (AU) 2023-03-28 — — US disclosed
EP-2865446-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL KANTO KAGAKU (JP) 2021-09-22 — — EP disclosed
US-20210214333-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING CTXT PTY LTD. (AU) 2021-07-15 — — US disclosed
US-8569281-B2 Compounds and their administration for treating a neurodegenerative disease as well as a method for identifying a compound capable of inhibiting a kinase, such as LRRK MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2013-10-29 — — US disclosed
EP-2619201-A1 PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 Medical Research Council Technology (GB) 2013-07-31 — — EP disclosed
US-20120295883-A1 COMPOUNDS GENENTECH, INC. (US) 2012-11-22 — — US disclosed
WO-2012038743-A1 PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2012-03-29 — — WO disclosed
EP-2408772-A1 COMPOUNDS Medical Research Council Technology (GB) 2012-01-25 — — EP disclosed
US-20100317646-A1 COMPOUNDS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-12-16 — — US disclosed
US-20100317646-A1 COMPOUNDS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-12-16 — — US disclosed
US-20100317646-A1 COMPOUNDS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-12-16 — — US disclosed
WO-2010106333-A1 COMPOUNDS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-09-23 — — WO disclosed
WO-2010106333-A1 COMPOUNDS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2010-09-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230227423-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING STING1, CGAS, IRF3 TYK2 1316/4885JAK2 1453/4885JAK1 1556/4885
US-20120295883-A1 COMPOUNDS ABCC5, PRNP, PC TYK2 3108/4885JAK2 2080/4885JAK1 3210/4885
US-20210214333-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING STING1, CGAS, IRF3 TYK2 1304/4885JAK2 1491/4885JAK1 1663/4885
US-11613525-B2 Substituted condensed thiophenes as modulators of sting STING1, CGAS, IRF3 TYK2 1304/4885JAK2 1491/4885JAK1 1663/4885
US-20100317646-A1 COMPOUNDS CBR3, CNR1, HCAR3 TYK2 1166/4885JAK2 1492/4885JAK1 3192/4885
US-20250092009-A1 SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING STING1, CGAS, IRF3 TYK2 1316/4885JAK2 1453/4885JAK1 1556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.