Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTPS1 | P17812 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27514260 | 0.92 | HSD17B1 (0.37) | KMT2AMEN1POLBCTPS1HSD11B1 | |
| SCHEMBL28744919 | 0.91 | KMT2A (0.36) | KMT2AMEN1POLBCTPS1CA2 | |
| SCHEMBL27513917 | 0.89 | KMT2A (0.41) | KMT2AMEN1POLBCTPS1MAPT | |
| SCHEMBL27534045 | 0.89 | KMT2A (0.36) | KMT2AMEN1POLBCTPS1HSD11B1 | |
| SCHEMBL28744904 | 0.88 | KMT2A (0.44) | KMT2AMEN1POLBCTPS1CA2 | |
| SCHEMBL27512542 | 0.87 | KMT2A (0.42) | KMT2AMEN1POLBCTPS1CA2 | |
| SCHEMBL28742120 | 0.86 | KMT2A (0.38) | KMT2AMEN1POLBCTPS1CA2 | |
| SCHEMBL27534024 | 0.86 | KMT2A (0.36) | KMT2AMEN1POLBCA2GAA | |
| SCHEMBL27534021 | 0.85 | CTPS1 (0.41) | KMT2AMEN1POLBCTPS1CA2 | |
| SCHEMBL27538347 | 0.85 | ALDH1A1 (0.36) | KMT2AMEN1POLBCTPS1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1249039-C | Inhibitors of 11 beta-hydroxysteroid dehydrogenase type I | BIOVITRUM AB (SE) | 2006-04-05 | — | — | CN | claimed |
| CN-1438997-A | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I | BIOVITRUM AB (SE) | 2003-08-27 | — | — | CN | claimed |
| CN-1249039-C | Inhibitors of 11 beta-hydroxysteroid dehydrogenase type I | BIOVITRUM AB (SE) | 2006-04-05 | — | — | CN | disclosed |
| CN-1438997-A | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I | BIOVITRUM AB (SE) | 2003-08-27 | — | — | CN | disclosed |