Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.51 |
| ▸ | RELA | Q04206 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633305 | 0.82 | F2RL3 (0.55) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL31239361 | 0.82 | F2RL3 (0.55) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL8059761 | 0.82 | MAPK1 (0.72) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL30851241 | 0.81 | KDM4E (0.69) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL2245749 | 0.81 | KDM4E (0.69) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL25027923 | 0.80 | KDM4E (0.71) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL26745312 | 0.79 | KDM4E (0.70) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL8070379 | 0.79 | KDM4E (0.75) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL5758901 | 0.78 | MAPT (0.57) | NPC1RAB9AKDM4EHSD17B10MAPT | |
| SCHEMBL3630700 | 0.78 | KDM4E (0.64) | NPC1RAB9AKDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1349990-A | Heterocyclic compound, its preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-22 | — | — | CN | disclosed |
| CN-1077107-C | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-02 | — | — | CN | disclosed |
| CN-1223653-A | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |