SCHEMBL2245749

SCHEMBL2245749

Cc1ccc2oc(-c3cccs3)nc2c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 9/20 0.69
▸ NPC1 O15118 8/20 0.69
▸ RAB9A P51151 8/20 0.69
▸ HSD17B10 Q99714 6/20 0.69
▸ TP53 P04637 6/20 0.69
▸ MAPT P10636 3/20 0.69
▸ GFER P55789 1/20 0.69
▸ ALDH1A1 P00352 10/20 0.63
▸ HPGD P15428 7/20 0.59
▸ SMN1; SMN2 Q16637 7/20 0.59
▸ CASP3 P42574 2/20 0.59
▸ SENP7 Q9BQF6 2/20 0.59
▸ SENP6 Q9GZR1 2/20 0.59
▸ POLB P06746 2/20 0.59
▸ SENP8 Q96LD8 1/20 0.59
▸ NFKB1 P19838 5/20 0.52
▸ NFKB2 Q00653 5/20 0.52
▸ RELA Q04206 5/20 0.52
▸ MAOA P21397 1/20 0.51
▸ MAOB P27338 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30851241 1.00 KDM4E (0.69) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL25027923 0.84 KDM4E (0.71) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL26745312 0.83 KDM4E (0.70) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL28822907 0.81 MAPT (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL27535586 0.81 NPC1 (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL30129338 0.81 KDM4E (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL3630700 0.81 KDM4E (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL28823008 0.81 MAPT (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL31344144 0.81 MAPT (0.64) KDM4ENPC1RAB9AHSD17B10TP53
SCHEMBL31239357 0.81 KDM4E (0.65) KDM4ENPC1RAB9AHSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108293281-B Method for manufacturing photoelectric conversion element AGC株式会社 2020-04-28 — — CN disclosed
CN-106674145-B The preparation method of 2- aryl benzoxazoles, 2- aryl benzothiazole compound 复旦大学 2019-11-12 — — CN disclosed
EP-3251694-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Summit (Oxford) Limited (GB) 2017-12-06 — — EP disclosed
CN-106674145-A Preparation method of 2-aryl benzoxazole and 2-aryl benzothiazole compounds 复旦大学 2017-05-17 — — CN disclosed
US-20140018320-A1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2014-01-16 — — US disclosed
US-20140011782-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2014-01-09 — — US disclosed
US-8518980-B2 Treatment of Duchenne muscular dystrophy SUMMIT CORPORATION PLC (GB) 2013-08-27 — — US disclosed
US-8501713-B2 Drug combinations for the treatment of duchenne muscular dystrophy SUMMIT CORPORATION PLC (GB) 2013-08-06 — — US disclosed
CN-101911832-B Organic electroluminescent display device and method for manufacturing same PANASONIC CORP 2013-06-19 — — CN disclosed
CN-102265422-A Organic electroluminescent device — 2011-11-30 — — CN disclosed
CN-1300521-A Organic electroluminescent device and method for manufacturing the same IDEMITSU KOSAN CO (JP) 2001-06-20 — — CN disclosed
CN-1290119-A Organic electroluminascent device and assembly, and method for controlling transmitted spectrum in device KIDO JUNJI (JP) 2001-04-04 — — CN disclosed
US-6171715-B1 ANODE AND CATHODE SEPARATED IN BETWEEN BY AN ORGANIC LAYER COMPRISING AN ARYLENE BIS(SUBSTITUTED BENZOX-, BENZOTHI-, OR BENZIMIDAZOLYL) ELECTROLUMINESCENT COMPOUND; EFFICIENCY, STABILITY FUJI PHOTO FILM CO., LTD. (JP) 2001-01-09 — — US disclosed
CN-1261760-A Organic electroluminescence device KIDO JUNJI (JP) 2000-08-02 — — CN disclosed
CN-1238655-A Organic electroluminescent devices JUNJI KIDO (JP) 1999-12-15 — — CN disclosed
CN-1236289-A Organic electroluminescent devices JUNJI KIDO (JP) 1999-11-24 — — CN disclosed
CN-1218604-A Multicolor organic element, method for manufacturing the same, and display using the same CHEMIPRO K K (JP) 1999-06-02 — — CN disclosed
EP-0903965-A1 MULTICOLOR ORGANIC EL ELEMENT, METHOD FOR MANUFACTURING THE SAME, AND DISPLAY USING THE SAME CHEMIPRO KASEI KAISHA, LIMITED (JP) 1999-03-24 — — EP disclosed
CN-1190322-A Organic Electroluminescent devices JUNJI KIDO (JP) 1998-08-12 — — CN disclosed
CN-1168132-A organic electroluminescent device, organic thin film and triamine compound IDEMITSU KOSAN CO (JP) 1997-12-17 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140011782-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY PYGM, CPT1B, GYS1 KDM4E 3311/4885NPC1 2477/4885RAB9A 3748/4885
US-20140018320-A1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY NR0B1, NR0B2, NR3C1 KDM4E 2080/4885NPC1 3637/4885RAB9A 4325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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