Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | NMBR | P28336 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046082 | 1.00 | ECE1 (0.45) | ECE1SMN1; SMN2PSMB1TSHRMAPT | |
| SCHEMBL7883345 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CTSLCTSBCTSS | |
| SCHEMBL7347883 | 0.82 | ECE1 (0.44) | ECE1SMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL7352891 | 0.82 | ECE1 (0.44) | ECE1SMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL7359411 | 0.79 | PSMB1 (0.44) | ECE1PSMB1CTSLCTSSCTSK | |
| SCHEMBL21663698 | 0.76 | CYP1A2 (0.46) | SMN1; SMN2HTTCTSLCTSBCTSS | |
| SCHEMBL18190841 | 0.76 | FOLH1 (0.51) | SMN1; SMN2 | |
| SCHEMBL21538566 | 0.76 | FOLH1 (0.51) | SMN1; SMN2 | |
| SCHEMBL27668713 | 0.75 | SMN1; SMN2 (0.46) | ECE1SMN1; SMN2TSHRMAPTKDM4E | |
| SCHEMBL27668711 | 0.75 | SMN1; SMN2 (0.46) | ECE1SMN1; SMN2TSHRMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268117-A | Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis | DU PONT PHARM CO (US) | 2000-09-27 | — | — | CN | disclosed |