Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.58 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234448 | 0.85 | FOLH1 (0.61) | FOLH1ANPEPENPEPMRGPRX4CYP2D6 | |
| SCHEMBL2343667 | 0.82 | FOLH1 (0.58) | FOLH1ANPEPENPEPMRGPRX4CYP2D6 | |
| SCHEMBL2707508 | 0.81 | FOLH1 (0.66) | FOLH1ANPEPENPEPCYP2D6CYP2C9 | |
| SCHEMBL29382329 | 0.81 | FOLH1 (0.66) | FOLH1ANPEPENPEPCYP2D6CYP2C9 | |
| SCHEMBL40857 | 0.80 | LOXL2 (0.67) | FOLH1MRGPRX4HIF1ARAB9AKMT2A | |
| SCHEMBL27972778 | 0.80 | LOXL2 (0.46) | FOLH1KMT2A | |
| SCHEMBL18095084 | 0.79 | FOLH1 (0.63) | FOLH1ANPEPENPEPCYP2D6CYP2C9 | |
| SCHEMBL7189829 | 0.78 | FOLH1 (0.61) | FOLH1ANPEPENPEPMRGPRX4CYP2D6 | |
| SCHEMBL13381194 | 0.78 | SRD5A2 (0.62) | FOLH1ANPEPENPEPCYP2D6CYP2C9 | |
| SCHEMBL9016835 | 0.78 | FOLH1 (0.61) | FOLH1ANPEPENPEPMRGPRX4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679404-A | piperidine-amide derivatives | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |
| CN-1268626-C | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |
| CN-1264825-C | Dihydro-benzo [ b ] [1,4] diazepin * -2-one derivatives as mGluR2 antagonists II | HOFFMANN LA ROCHE (CH) | 2006-07-19 | — | — | CN | disclosed |
| CN-1535266-A | Dihydro-benzo [b][1,4] diazepin-2-one derivatives as mglur 2 antagonists II | - | 2004-10-06 | — | — | CN | disclosed |
| CN-1522252-A | Dihydro-benzo(b)(1,4)diazepin-2-one derivatives as mglur2 antagonists I | - | 2004-08-18 | — | — | CN | disclosed |