SCHEMBL27543793

SCHEMBL27543793

CC(C)N(CC(F)(F)F)c1ccc2c(c1)c(C(F)(F)F)cc(=O)n2N

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 0.61
PGR P06401 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1770781 0.76 AR (1.00) AR
SCHEMBL27518208 0.72 KDM4E (0.39) ARPGR
SCHEMBL1771589 0.72 AR (0.54) AR
SCHEMBL1771424 0.70 AR (0.52) ARPGR
SCHEMBL27536679 0.70 HTR1D (0.38) ARPGR
SCHEMBL27518959 0.67 ALDH1A1 (0.42) AR
SCHEMBL27543726 0.67 AGER (0.36) AR
SCHEMBL1772070 0.67 AR (0.67) AR
SCHEMBL27543777 0.66 AR (0.36) AR
SCHEMBL1771174 0.66 AR (0.48) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100384823-C Bicyclic androgen and progesterone receptor modulator compounds and methods LIGAND PHARM INC (US) 2008-04-30 CN disclosed
CN-101029042-A Bicyclic androgen and progesterone receptor modulator compounds and methods LIGAND PHARM INC (US) 2007-09-05 CN disclosed
CN-1262540-C Bicyclic androgen and progesterone receptor modulating compounds and methods LIGAND PHARM INC (US) 2006-07-05 CN disclosed
CN-1775759-A Bicyclic androgen and progesterone receptor modulator compounds and methods LIGAND PHARM INC (US) 2006-05-24 CN disclosed