Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926454 | 0.93 | NISCH (0.34) | NISCHKDM4EGAAPTPN1ALPL | |
| SCHEMBL1029739 | 0.77 | SLC6A3 (0.40) | NISCHKDM4EGAAPTPN1ALPL | |
| Hydrochloric Acid SCHEMBL27537067 | 0.77 | NISCH (0.38) | NISCHKDM4EGAAPTPN1ALPL | |
| SCHEMBL19593316 | 0.72 | PTPN1 (0.41) | NISCHKDM4EGAAPTPN1ALPL | |
| Hydrochloric Acid SCHEMBL7938955 | 0.71 | NISCH (0.34) | NISCHKDM4EGAAPTPN1ALPL | |
| Hydrochloric Acid SCHEMBL7935976 | 0.69 | NISCH (0.33) | NISCHKDM4EGAAPTPN1ALPL | |
| Hydrochloric Acid SCHEMBL7935997 | 0.69 | NISCH (0.33) | NISCHKDM4EGAAPTPN1ALPL | |
| Hydrochloric Acid SCHEMBL7938961 | 0.69 | PTPN1 (0.33) | NISCHKDM4EGAAPTPN1ALPL | |
| SCHEMBL1821397 | 0.68 | SLC6A3 (0.38) | NISCHKDM4EGAAPTPN1ALPL | |
| SCHEMBL3388511 | 0.68 | HPRT1 (0.44) | ALDH1A1MAPTHPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1274359-A | Mu-oxometallocene complex compound, and olefin polymerization catalyst and polymerization method using same | CHISSO CORP (JP) | 2000-11-22 | — | — | CN | disclosed |
| CN-1274360-A | Processes for prepn. of metallocene complexes | CHISSO CORP (JP) | 2000-11-22 | — | — | CN | disclosed |