Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | FLT1 | P17948 | 7/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27485595 | 0.90 | KDR (0.60) | NAMPTKDRFLT1MAPTABL1 | |
| SCHEMBL27466657 | 0.85 | PTGS1 (0.64) | KDRFLT1P2RX1GAATSHR | |
| SCHEMBL27468045 | 0.82 | KDR (0.44) | KDRFLT1GAAMAPTHTT | |
| SCHEMBL27486254 | 0.81 | SMN1; SMN2 (0.53) | NAMPTKDRMAPTHTTALDH1A1 | |
| SCHEMBL27485938 | 0.81 | PRKCI (0.53) | KDRFLT1MAPTABL1EGFR | |
| SCHEMBL27465575 | 0.81 | P2RX1 (0.50) | KDRFLT1P2RX1MAPTHTT | |
| SCHEMBL27484538 | 0.81 | CYP17A1 (0.56) | KDRFLT1MAPTHTTALDH1A1 | |
| SCHEMBL27548625 | 0.81 | KDR (0.59) | NAMPTKDRFLT1P2RX1MAPT | |
| SCHEMBL27508410 | 0.80 | KCNK3 (0.45) | KDRFLT1MAPTALDH1A1HPGD | |
| SCHEMBL27485244 | 0.80 | ALDH1A1 (0.52) | KDRGAAMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1331680-A | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-01-16 | — | — | CN | claimed |
| CN-1152014-C | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | ��˹��ŵ�� | 2004-06-02 | — | — | CN | disclosed |
| CN-1331680-A | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-01-16 | — | — | CN | disclosed |