SCHEMBL27549596

SCHEMBL27549596

COC(=O)C(Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1(CCc2ccccc2)CCCC1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.48
ATM Q13315 2/20 0.47
CTSL P07711 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
ALDH1A1 P00352 1/20 0.47
THRB P10828 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HSD17B10 Q99714 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
SSTR3 P32745 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27549594 1.00 MMP1 (0.48) MMP1ATMCTSLMEN1KMT2A
SCHEMBL6628979 0.90 ITGB1 (0.50) MMP1ATMMEN1KMT2AALDH1A1
SCHEMBL6585794 0.87 ITGB1 (0.53) MMP1KMT2A
SCHEMBL27546176 0.87 ITGB1 (0.53) MMP1KMT2A
SCHEMBL27572950 0.85 MMP1 (0.52) MMP1ATMALDH1A1THRBCYP2C9
SCHEMBL27572948 0.85 MMP1 (0.52) MMP1ATMALDH1A1THRBCYP2C9
Trifluoroacetic Acid SCHEMBL6581814 0.83 ITGB1 (0.46) MMP1SSTR3
SCHEMBL6630790 0.82 ITGA4 (0.57) ATMMEN1KMT2ACYP2C9CYP2C19
SCHEMBL6580207 0.82 ITGB1 (0.53) MMP1KMT2A
SCHEMBL6631425 0.82 ITGB1 (0.62)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1276785-A N-aroylphenylalanine derivs. HOFFMANNN LA ROCHE AG F (CH) 2000-12-13 CN disclosed