Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL1128189 | 0.93 | CXCR4 (0.53) | HIF1AMAPTPDE4AKDRADRB2 | |
| Pyrazine SCHEMBL28417538 | 0.89 | CXCR4 (0.60) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperidine SCHEMBL1269716 | 0.87 | ALDH1A1 (0.56) | HIF1AMAPTPDE4AKDRADRB2 | |
| Pyrazine SCHEMBL27923542 | 0.85 | HIF1A (0.33) | HIF1AMAPTPDE4AKDRADRB2 | |
| Pyrazine SCHEMBL4071877 | 0.85 | ALDH1A1 (0.53) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperidine SCHEMBL2418231 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperazine SCHEMBL28156489 | 0.82 | TSHR (0.60) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperazine SCHEMBL1699696 | 0.82 | TSHR (0.60) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperazine SCHEMBL27917020 | 0.82 | TSHR (0.60) | HIF1AMAPTPDE4AKDRADRB2 | |
| Piperazine SCHEMBL27982866 | 0.82 | TSHR (0.60) | HIF1AMAPTPDE4AKDRADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407970-A | Preparation method, pure color material and the liquid crystal display device of dye stuff of rhodamine kinds monomeric oligomeric conjunction object | SHENZHEN CHINA STAR OPTOELECT | 2019-11-05 | — | — | CN | disclosed |
| CN-109980114-A | Light-emitting component, display device, electronic equipment and lighting device | 株式会社半导体能源研究所 | 2019-07-05 | — | — | CN | disclosed |
| CN-109841746-A | Light-emitting component, display device, electronic equipment and lighting device | 株式会社半导体能源研究所 | 2019-06-04 | — | — | CN | disclosed |
| CN-108697646-A | Pharmaceutical compositions and methods for combating chemotherapy-induced cardiotoxicity | 干细胞诊疗公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108349936-A | It is used to treat N- [2- (1- benzyl piepridine -4- bases) ethyl] -4- (pyrazine -2- bases)-piperazine -1- carboxamides derivatives and related compound of neurological disorder as muscarinic receptor 4 (M4) antagonist | 纽罗克里生物科学有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108350021-A | Compound for treating ophthalmology disease and preparation | 视点医疗公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108075044-A | Light-Emitting Element, Display Device, Electronic Device, and Lighting Device | 株式会社半导体能源研究所 | 2018-05-25 | — | — | CN | disclosed |
| CN-103433050-B | Preparation method of catalyst for synthesizing piperazine through monoethanolamine catalytic amination one-step method | ZHEJIANG LYUKEAN CHEMICAL CO LTD | 2015-02-25 | — | — | CN | disclosed |
| CN-103433050-A | Preparation method of catalyst for synthesizing piperazine through monoethanolamine catalytic amination one-step method | ZHEJIANG LYUKEAN CHEMICAL CO LTD | 2013-12-11 | — | — | CN | disclosed |
| CN-100429077-C | Water-based ink, recorded image using the same, and method for forming image | CANON KK (JP) | 2008-10-29 | — | — | CN | disclosed |
| CN-1742061-A | Water-based ink, recorded image using the same, and method for forming image | CANON KK (JP) | 2006-03-01 | — | — | CN | disclosed |
| CN-1332205-A | Radiation-sensitive resin composition | JSR CORP (JP) | 2002-01-23 | — | — | CN | disclosed |