Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088326 | 0.73 | CHEK2 (0.44) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL30507791 | 0.72 | KDM4E (0.50) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL2722136 | 0.71 | KDM4E (0.55) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL31000763 | 0.70 | DHODH (0.48) | KDM4ECSNK2A2CSNK2BGRM2TDP1 | |
| SCHEMBL2723566 | 0.70 | KDM4E (0.49) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL31000786 | 0.69 | MKNK1 (0.52) | CSNK2A2CSNK2BKMT2ACSNK2A1PIM1 | |
| SCHEMBL25082427 | 0.68 | KDM4E (0.46) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL11400984 | 0.68 | KDM4E (0.43) | KDM4EGLACSNK2A2CSNK2BLCK | |
| SCHEMBL2723700 | 0.68 | KDM4E (0.59) | KDM4EGLAKMT2ATDP1NPC1 | |
| SCHEMBL30507784 | 0.68 | DYRK1A (0.47) | KDM4EGLACSNK2A2CSNK2BGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1289087-C | Quinoline derivatives as neuropeptide y antagonists | HOFFMANN LA ROCHE (CH) | 2006-12-13 | — | — | CN | disclosed |
| CN-1607951-A | Quinoline derivatives as neuropeptide y antagonists | HOFFMANN LA ROCHE (CH) | 2005-04-20 | — | — | CN | disclosed |