Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK1 | P23458 | 7/20 | 0.41 |
| ▸ | TYK2 | P29597 | 7/20 | 0.41 |
| ▸ | JAK3 | P52333 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722158 | 0.82 | KMT2A (0.58) | KDM4EGLATDP1KMT2ANPC1 | |
| SCHEMBL2722136 | 0.77 | KDM4E (0.55) | KDM4EGLATDP1KMT2ANPC1 | |
| SCHEMBL29260843 | 0.75 | SMN1; SMN2 (0.49) | KDM4EGLATDP1KMT2AMAPK1 | |
| SCHEMBL1521056 | 0.73 | KDM4E (0.64) | KDM4EKMT2AMAPK1MEN1ALDH1A1 | |
| SCHEMBL30507791 | 0.72 | KDM4E (0.50) | KDM4EGLATDP1KMT2ANPC1 | |
| SCHEMBL6922909 | 0.72 | MAPK1 (0.51) | KDM4EGLATDP1KMT2ANPC1 | |
| SCHEMBL17950444 | 0.72 | KDM4E (0.50) | KDM4EGLATDP1KMT2ANPC1 | |
| SCHEMBL2119122 | 0.71 | HDAC6 (0.49) | — | |
| SCHEMBL3727866 | 0.71 | KMT2A (0.67) | KDM4EKMT2ANPC1RAB9AJAK2 | |
| SCHEMBL2118762 | 0.69 | ALDH1A1 (0.55) | KDM4ETDP1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054332-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |