Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MDM4 | O15151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28063105 | 0.85 | L3MBTL1 (0.55) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL28063106 | 0.85 | L3MBTL1 (0.53) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL27905665 | 0.82 | HTT (0.51) | L3MBTL1POLBALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL11405720 | 0.81 | L3MBTL1 (0.51) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL27810581 | 0.80 | L3MBTL1 (0.48) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL28252340 | 0.80 | L3MBTL1 (0.47) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL28252343 | 0.80 | L3MBTL1 (0.43) | L3MBTL1MDM4TP53CETPPOLB | |
| SCHEMBL8631475 | 0.79 | ALDH1A1 (0.55) | POLBALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL24420075 | 0.79 | POLB (0.55) | L3MBTL1POLBALDH1A1HTTMAPT | |
| SCHEMBL27483868 | 0.78 | GAA (0.50) | L3MBTL1POLBALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101417964-A | Use of compounds for the elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2009-04-29 | — | — | CN | disclosed |
| CN-1303281-A | Application of compound in enhancing activity of pyruvate dehydrogenase | ASTRA ZENECA LTD (SE) | 2001-07-11 | — | — | CN | disclosed |