Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042658 | 0.82 | ALOX15 (0.33) | KDM4E | |
| SCHEMBL18322605 | 0.78 | POLB (0.38) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL5046445 | 0.78 | — | — | |
| SCHEMBL26455 | 0.78 | ALDH1A1 (0.35) | KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5042569 | 0.77 | USP2 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL27672127 | 0.77 | POLB (0.37) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL27519970 | 0.77 | POLB (0.37) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL5042450 | 0.76 | ALOX15 (0.35) | — | |
| SCHEMBL27469787 | 0.76 | ALOX15 (0.35) | — | |
| SCHEMBL197847 | 0.76 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1626069-A | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy | WARNER LAMBERT CO (US) | 2005-06-15 | — | — | CN | claimed |
| CN-1344245-A | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | WARNER LAMBER CO (US) | 2002-04-10 | — | — | CN | claimed |
| CN-1626069-A | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of diabetic retinopathy | WARNER LAMBERT CO (US) | 2005-06-15 | — | — | CN | disclosed |
| CN-1170811-C | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | ��ʲ | 2004-10-13 | — | — | CN | disclosed |
| CN-1344245-A | Inhibitors of branched chain amino acid dependent aminotransferases and their use in the treatment of diabetic retinopathy | WARNER LAMBER CO (US) | 2002-04-10 | — | — | CN | disclosed |