Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24487004 | 0.96 | S1PR2 (0.44) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL24486994 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL9230533 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL27716910 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL22372313 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL3806762 | 0.80 | EPHX2 (0.56) | SMN1; SMN2NPC1RAB9AGAALMNA | |
| SCHEMBL27466796 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL17342588 | 0.80 | PADI3 (0.53) | SMN1; SMN2NPC1RECQLRAB9AGAA | |
| SCHEMBL5803249 | 0.79 | NPC1 (0.62) | SMN1; SMN2NPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL29053488 | 0.79 | PLAU (0.50) | SMN1; SMN2NPC1RECQLRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1656107-A | Plasma carboxypeptidase B inhibitors | SCHERING AG (DE) | 2005-08-17 | — | — | CN | claimed |
| CN-1332964-C | Plasma carboxypeptidase B inhibitors | SCHERING AG (DE) | 2007-08-22 | — | — | CN | disclosed |
| CN-1656107-A | Plasma carboxypeptidase B inhibitors | SCHERING AG (DE) | 2005-08-17 | — | — | CN | disclosed |