Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.81 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.81 |
| ▸ | PGR | P06401 | 3/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | SHBG | P04278 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL28035734 | 0.94 | HIF1A (0.79) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL27724729 | 0.92 | HIF1A (0.83) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL365193 | 0.91 | HIF1A (0.83) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL29200407 | 0.91 | HIF1A (0.79) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL11431210 | 0.91 | HIF1A (0.94) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL28687829 | 0.90 | HIF1A (0.83) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL1807734 | 0.90 | HIF1A (0.83) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL122188 | 0.90 | HIF1A (0.83) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL4697 | 0.90 | HIF1A (0.86) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 | |
| Hydrocortisone SCHEMBL28908729 | 0.90 | HIF1A (0.86) | HIF1ANR3C2NR3C1PGRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573913-B | Inhibit the acid-addition salts of the compound of Trk | 小野药品工业株式会社 | 2019-11-19 | — | — | CN | disclosed |
| CN-110225908-A | Ethanesulfonic acid salt of quinoline derivative | 小野药品工业株式会社 | 2019-09-10 | — | — | CN | disclosed |
| CN-109111446-A | A kind of heteroaryl compound with pharmaceutical activity | 上海度德医药科技有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-109073640-A | Severity of atopic dermatitis in local skin and index of therapeutic effect | 株式会社资生堂 | 2018-12-21 | — | — | CN | disclosed |
| CN-107872972-A | Topical composition comprising corticosteroid | 普罗缪斯制药有限责任公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-106659682-A | Topical corticosteroid compositions | 普罗缪斯制药有限责任公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-101115709-B | Aminocarboxylic acid derivative and medical use thereof | ONO PHARMACEUTICAL CO | 2011-04-13 | — | — | CN | disclosed |
| CN-1361688-A | External preparation for skin diseases containing nitroimidazole | SHOEI CO LTD (JP) | 2002-07-31 | — | — | CN | disclosed |