Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29844446 | 1.00 | CDK5 (0.37) | CDK5CDK5R1HRH3TSHRPOLB | |
| SCHEMBL29844508 | 1.00 | CDK5 (0.37) | CDK5CDK5R1HRH3TSHRPOLB | |
| Hydrochloric Acid SCHEMBL27734241 | 0.98 | CDK5 (0.36) | CDK5CDK5R1HRH3TSHRPOLB | |
| Hydrochloric Acid SCHEMBL1114916 | 0.98 | CDK5 (0.36) | CDK5CDK5R1HRH3TSHRPOLB | |
| SCHEMBL29844647 | 0.91 | HTR2A (0.47) | CDK5CDK5R1HRH3TSHRPOLB | |
| SCHEMBL1230997 | 0.91 | HTR2A (0.47) | CDK5CDK5R1HRH3TSHRPOLB | |
| SCHEMBL14327287 | 0.89 | ALDH1A1 (0.36) | CDK5CDK5R1HRH3TSHRGAA | |
| SCHEMBL12009751 | 0.85 | — | — | |
| SCHEMBL19682135 | 0.79 | GAA (0.34) | HRH3POLBGAAALDH1A1RAB9A | |
| SCHEMBL12336639 | 0.78 | ESR1 (0.37) | CDK5CDK5R1TSHRPOLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10130720-B2 | Composition comprising a polymeric reagent | NEKTAR THERAPEUTICS (US) | 2018-11-20 | — | — | US | claimed |
| US-20170348426-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS | 2017-12-07 | — | — | US | claimed |
| CN-110591079-B | Preparation method of monofunctional nonlinear polyethylene glycol | 厦门赛诺邦格生物科技股份有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-20220143201-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS (US) | 2022-05-12 | — | — | US | disclosed |
| US-20220143201-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS (US) | 2022-05-12 | — | — | US | disclosed |
| US-11266742-B2 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS (US) | 2022-03-08 | — | — | US | disclosed |
| US-20200276320-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS (US) | 2020-09-03 | — | — | US | disclosed |
| US-20200276320-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS (US) | 2020-09-03 | — | — | US | disclosed |
| US-10695435-B2 | Composition comprising a polymeric reagent | NEKTAR THERAPEUTICS (US) | 2020-06-30 | — | — | US | disclosed |
| US-10695435-B2 | Composition comprising a polymeric reagent | NEKTAR THERAPEUTICS (US) | 2020-06-30 | — | — | US | disclosed |
| CN-110591079-A | Preparation method of monofunctional nonlinear polyethylene glycol | 厦门赛诺邦格生物科技股份有限公司 | 2019-12-20 | — | — | CN | disclosed |
| EP-1896082-A2 | CONJUGATES HAVING A DEGRADABLE LINKAGE AND POLYMERIC REAGENTS USEFUL IN PREPARING SUCH CONJUGATES | Nektar Therapeutics AL, Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007075534-A2 | POLYMER CONJUGATES OF GLP-1 | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | NEKTAR THERAPEUTICS | 2007-04-26 | — | — | US | disclosed |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | NEKTAR THERAPEUTICS | 2007-04-26 | — | — | US | disclosed |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | NEKTAR THERAPEUTICS | 2007-04-26 | — | — | US | disclosed |
| WO-2007019331-A2 | CONJUGATES OF A G-CSF MOIETY AND A POLYMER | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007019331-A2 | CONJUGATES OF A G-CSF MOIETY AND A POLYMER | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20060293499-A1 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS | 2006-12-28 | — | — | US | disclosed |
| WO-2006138572-A2 | CONJUGATES HAVING A DEGRADABLE LINKAGE AND POLYMERIC REAGENTS USEFUL IN PREPARING SUCH CONJUGATES | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143201-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | CDK5 3508/4885CDK5R1 3632/4885HRH3 123/4885 |
| US-20200276320-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | CDK5 3508/4885CDK5R1 3632/4885HRH3 123/4885 |
| US-10130720-B2 | Composition comprising a polymeric reagent | CD44, FCGRT, C9 | CDK5 3508/4885CDK5R1 3632/4885HRH3 123/4885 |
| US-11266742-B2 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | CD44, DNPEP, SI | CDK5 2593/4885CDK5R1 2803/4885HRH3 260/4885 |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | CSF3R, GMFG, CSF1R | CDK5 4207/4885CDK5R1 4402/4885HRH3 824/4885 |
| US-20170348426-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | CDK5 3508/4885CDK5R1 3632/4885HRH3 123/4885 |
| US-10695435-B2 | Composition comprising a polymeric reagent | CD44, FCGRT, C9 | CDK5 3508/4885CDK5R1 3632/4885HRH3 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.