Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.44 |
| ▸ | HTR1D | P28221 | 7/20 | 0.44 |
| ▸ | HTR1B | P28222 | 6/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HTR7 | P34969 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27483636 | 0.89 | HTR1D (0.48) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8707969 | 0.84 | DRD2 (0.42) | CCR2DRD2SLC6A4HTR1ADRD3 | |
| SCHEMBL8707108 | 0.81 | SLC6A4 (0.43) | HTR1DHTR1BMAPTBLMNPSR1 | |
| SCHEMBL27527184 | 0.81 | HTR1D (0.50) | CCR2HTR1DHTR1BDRD2CHRM2 | |
| SCHEMBL7479525 | 0.78 | HTR1D (0.48) | CCR2HTR1DHTR1BDRD2CHRM2 | |
| SCHEMBL7481757 | 0.77 | HTR1D (0.55) | HTR1DHTR1BDRD2CHRM2HTR1A | |
| SCHEMBL7487120 | 0.77 | CCR2 (0.61) | CCR2HTR1DHTR1BDRD2CHRM2 | |
| SCHEMBL27498570 | 0.75 | HTR1D (0.51) | CCR2HTR1DHTR1BDRD2CHRM2 | |
| SCHEMBL27498200 | 0.75 | HTR1D (0.49) | HTR1DHTR1BDRD2CHRM2HTR2A | |
| SCHEMBL27496223 | 0.75 | HTR1D (0.65) | HTR1DHTR1BDRD2CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1184425-A | 5-substituted-3- (1,2,3, 6-tetrahydropyridin-4-yl) -and 3- (piperidin-4-yl) -1H-indoles, 5-HT1FAgonists | LILLY CO ELI (US) | 1998-06-10 | — | — | CN | disclosed |