Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.48 |
| ▸ | CDK2 | P24941 | 10/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34470513 | 0.75 | CDK1 (0.61) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL27573678 | 0.74 | CDK2 (0.58) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL22587405 | 0.73 | CDK1 (0.58) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL3696799 | 0.71 | CCNA2 (0.51) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL5827777 | 0.70 | CDK5 (0.79) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL6821040 | 0.70 | CDK2 (0.63) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL29426182 | 0.70 | CDK2 (0.56) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL539356 | 0.70 | CDK2 (0.56) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL19112003 | 0.70 | CDK1 (0.61) | CDK1CDK5CDK5R1CDK2CCNA2 | |
| SCHEMBL19112004 | 0.69 | CDK2 (0.55) | CDK1CDK5CDK5R1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1353713-A | Purine inhibitors of cyclin dependent kinase 2 and IK B-alpha | CV THERAPEUTICS INC (US) | 2002-06-12 | — | — | CN | disclosed |